Combining Ambrisentan and Tadalafil provides improved treatment outcome in PAH

Combination of Ambrisentan and Tadalafil

Pharmacological agents with different mechanisms of action are often used in combination for the treatment of many health conditions. There is the proposition in medicine that combining pharmacological agents with different mechanisms generally provides superior results than increasing the dosage of a single agent. When we increase the dosage of a medication, every increment of efficacy is coupled with an increase in the risk for adverse effects. Combining agents with different mechanisms of actions can often produce the same desired therapeutic effect at lower doses of each agent. In the treatment of pulmonary hypertension, the combination associated with the best efficacy that we know today, is the combination of tadalafil and ambrisentan for patients with WHO functional class II or III pulmonary arterial hypertension (PAH). Continue reading