Ambrisentan for the treatment of pulmonary hypertension (PAH)

What is Ambrisentan?

Ambrisentan (brand named Letairis in the U.S., Volibris in the European Union and Canada) is an FDA-approved oral medication for the treatment of pulmonary hypertension. It is recommended by the FDA for patients with WHO class II and class III symptoms of pulmonary arterial hypertension (PAH) to improve exercise tolerance and slow down disease progression. The price for ambrisentan is over $10,000 per month in many countries, you can buy ambrisentan from our online pharmacy at an affordable price.

Ambrisentan is an endothelin receptor antagonist (ETA). It selectively inhibits the endothelin type-A (ETA) receptor. Endothelin-1 (ET-1) is a protein molecule our body makes for the purpose of cell to cell signaling. and ETA and ETB are receptors for ET-1 found on the smooth muscle cells of our blood vessels to mediate the effect of ET-1. When ET-1 binds with ETA  receptors, the blood vessels constrict, and blood pressure rises. When ET-1 binds with ETB receptors, the blood vessels dilate, and blood pressure drops. Continue reading